Mendelian randomization analyses of smoking and Alzheimer’s disease in Chinese and Japanese populations

Zhu, Yuan and Guan, Ying and Xiao, Xuewen and Jiao, Bin and Liao, Xinxin and Zhou, Hui and Liu, Xixi and Qi, Feiyan and Peng, Qiyuan and Zhou, Lu and Xu, Tianyan and Yang, Qijie and Zhang, Sizhe and Li, Meng and Zhu, Zhouhai and Lu, Sheming and Li, Jinchen and Tang, Beisha and Shen, Lu and Yao, Jianhua and Zhou, Yafang (2023) Mendelian randomization analyses of smoking and Alzheimer’s disease in Chinese and Japanese populations. Frontiers in Aging Neuroscience, 15. ISSN 1663-4365

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Abstract

Background: Previous epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer’s disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis.

Methods: We used single nucleotide polymorphisms (SNPs) associated with smoking quantity (cigarettes per day, CPD) from genome-wide association studies (GWAS) of Japanese population as instrumental variables, then we performed two-sample MR analysis to investigate the association between smoking and AD in a Chinese cohort (1,000 AD cases and 500 controls) and a Japanese cohort (3,962 AD cases and 4,074 controls), respectively.

Results: Genetically higher smoking quantity showed no statistical causal association with AD risk (the inverse variance weighted (IVW) estimate in the Chinese cohort: odds ratio (OR) = 0.510, 95% confidence interval (CI) = 0.149–1.744, p = 0.284; IVW estimate in the Japanese cohort: OR = 1.170, 95% confidence interval CI = 0.790–1.734, p = 0.434).

Conclusion: This MR study, for the first time in Chinese and Japanese populations, found no significant association between smoking and AD.

Item Type: Article
Subjects: STM Archives > Medical Science
Depositing User: Unnamed user with email support@stmarchives.com
Date Deposited: 14 Jul 2023 11:37
Last Modified: 25 May 2024 09:12
URI: http://science.scholarsacademic.com/id/eprint/1411

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