Nuzzo, Domenico and Picone, Pasquale and Giardina, Costanza and Scordino, Miriana and Mudò, Giuseppa and Pagliaro, Mario and Scurria, Antonino and Meneguzzo, Francesco and Ilharco, Laura M. and Fidalgo, Alexandra and Alduina, Rosa and Presentato, Alessandro and Ciriminna, Rosaria and Di Liberto, Valentina (2021) New Neuroprotective Effect of Lemon IntegroPectin on Neuronal Cellular Model. Antioxidants, 10 (5). p. 669. ISSN 2076-3921
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Abstract
Lemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity in vitro, as first reported in this study investigating the effects of both lemon IntegroPectin and commercial citrus pectin on cell viability, cell morphology, reactive oxygen species (ROS) production, and mitochondria perturbation induced by treatment of neuronal SH-SY5Y human cells with H2O2. Mediated by ROS, including H2O2 and its derivatives, oxidative stress alters numerous cellular processes, such as mitochondrial regulation and cell signaling, propagating cellular injury that leads to incurable neurodegenerative diseases. These results, and the absence of toxicity of this new pectic substance rich in adsorbed flavonoids and terpenes, suggest further studies to investigate its activity in preventing, retarding, or even curing neurological diseases.
Item Type: | Article |
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Subjects: | STM Archives > Agricultural and Food Science |
Depositing User: | Unnamed user with email support@stmarchives.com |
Date Deposited: | 17 May 2024 10:42 |
Last Modified: | 17 May 2024 10:42 |
URI: | http://science.scholarsacademic.com/id/eprint/1423 |