Diabetes Insipidus–Is it a Sequelae of COVID-19 Infection?

Introduction: COVID-19 has diverse clinical presentations. We are now quite familiar with the usual symptoms---fever, cough, breathlessness, anosmia, fatigue. Diabetes insipidus could also be a symptom related to covid-19 or it can be a post covid complication.

Case Report: This is a case of a 40 years old patient who presented to the emergency department with breathlessness and desaturation. He was treated with non-invasive ventilation and steroids. His clinical status improved subsequently and he was discharged after 1 week. After two days of discharge, he developed polyuria, hypernatremia, dehydration and hypotension. We performed a water deprivation test and confirmed a diagnosis of neurogenic diabetes insipidus.

Discussion: Diabetes insipidus is a disorder of water homeostasis characterized by polyuria. It is possible that SARS Cov-2 virus due to its predilection for ACE 2 receptors enters hypothalamus and affects the neuronal secretion of vasopressin.

Conclusion: Diabetes insipidus could be one of the delayed manifestations of the disease.It is possible that SARS-Cov2 virus has a possible endocrinopathic effect.