Changes of blood gas and serum indexes in patients with acute heart failure complicated with respiratory failure treated by noninvasive ventilator

Objective: To observe the changes of blood gas and serum indexes in patients with acute heart failure complicated with respiratory failure treated by noninvasive ventilator-assisted ventilation.

Methods: The records of patients with acute heart failure and respiratory failure, treated in our hospital from June 2019 to June 2021, were selected and stratified based on the received therapy. Of a total of 168 patients, 81 received continuous low flow oxygen therapy (control group) and 87 received noninvasive ventilator (NIV)-assisted ventilation therapy (NIV group). The blood gas and serum indexes of the two groups were compared and analyzed.

Results: After 48 hours of treatment, the blood oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2) and oxygenation index (PaO2/FiO2) in patients in the NIV group were higher than those in the control group, while the expression of arterial partial pressure of carbon dioxide (PaCO2) was lower than that in the control group (P<0.05). After 24 hours and 48 hours of treatment, there was an increase in the expression of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) and Cardiac troponin I (cTnI) in both groups. The expression of NT-pro BNP and cTnI in the NIV group was significantly lower than that in the control group (P<0.05).

Conclusion: In patients with acute heart failure and respiratory failure, noninvasive ventilator-assisted ventilation results in improved blood gas analysis indexes and lower levels of heart disease markers, NT-pro BNP and cTnI.