Paraneoplastic Nephrotic Syndrome in Breast Cancer HCV Positive- A Case Report

Aims: Our aim was to illustrate a case of Membranous Glomerulopathy (MG), which is the commonest paraneoplastic pathology associated with the nephrotic syndrome, and develops in parallel with salient/ unapparent cancer evolution phases.

Presentation of Case: We present a rare case of a 39-year-old female patient with nephrotic syndrome considered secondary to a Hepatitis C with elevated viremia and to a breast cancer (BC), which was lately revealed by Ductal Echography (DE) and confirmed by Mammography and fine-needle aspiration biopsy, with BC staged T4NxMx.

Discussion: The nephrotic syndrome is usually considered as idiopathic, at least in the initial stage. Some other diseases may be incriminated as etiological factors in the secondary nephrotic syndrome, with simultaneous evolution and improvement/healing of the nephrotic impairment after the removing of the associated disease.

Conclusion: The paraneoplastic nephrotic syndrome associated to BC is a rare condition, and the best cost-efficient method of diagnosis could be the anatomical technique of Ultrasonography / DE, which is not operator dependent and allows the accurate detection of breast malignancy, suitable in earlier stages. Otherwise, some cases are missed or diagnosed in advanced stages, such in this presentation.